Granular Y molecular sieve loaded with iron nanoparticles with cation exchange performance was synthesized for simultaneous removal of Cu(Ⅱ) and Cr(Ⅵ) from aqueous solution. The results show that the adsorption capacity of Cu(Ⅱ) increases from 46.6 mg/g to 67.6 mg/g, and the adsorption capacity of Cr(Ⅵ) is 13.2 mg/g when using granular Y molecular sieve loaded with iron nanoparticles. The removal of Cr(Ⅵ) by the loaded material is improved due to the coexistence of Cu(Ⅱ). The removal mechanism of Cu(Ⅱ) by the loaded material involves the cation exchange of Y molecular sieve and the reduction of Fe(0). The removal of Cr(Ⅵ) is mainly attributed to the reduction of Fe(0), and the reductive products of Cu(Ⅱ) can promote the removal of Cr(Ⅵ) by the loaded material.