ing at the industrial images with uneven illumination interference, a local threshold segmentation method based on multi-direction grayscale wave for image is proposed in this paper. First, the image is pretreated with mean filtering. Then, one-dimensional grayscale wave curves are extracted in four-direction of horizontal, vertical, left diagonal and right diagonal. Meanwhile, one-dimension local threshold segmentation is carried out for wave peaks and troughs which satisfy the threshold condition of wave amplitude on each curve. Finally, an and operation is processed for segmented sub-images, the final segmented image is obtained. The experimental results show that this method can effectively improve the segmentation accuracy of images with uneven illumination. Compared with two-dimensional Otsu, two-dimensional Tsallis and Niblack methods, the segmentation effect of the proposed method is significantly improved.