A method to correct thermal calculation parameters based on the Center Composite Design (CCD) was presented for enhancing the thermal analysis accuracy of a space camera. Firstly, the CCD was introduced,and the thermal tests of second mirror and baffle for the space camera were summarized. The finite element mode of the thermal tests was established and the thermal analysis was dealt with by a software code TMG at different load cases. The parameters of thermal analysis were designed by means of the CCD,then they were taken as the different load cases for the thermal analysis. The regression equations about the highest temperature of second mirror,free convection coefficient and the contact coefficient of heat transfer were fitted according to the results of thermal analysis. The final thermal calculation parameters were obtained by solving the regression equations based on the test results. Finally, the thermal analysis was dealt with again by the parameters that had been solved. The results show that the calculation results of parameters corrected are in agreement with the results of thermal test well,and the relative error is 2%. Moreover,the method can be applied to the thermal analysis of other space cameras and shows a good universality.