To realize the initial design and experimental verification of wearable flexible electronics, an electronic rapid preparation method based on “cutting and pasting” was proposed. First, a micro-nano patterning process based on laser cutting was presented by a comparison with photolithography and inkjet printing processes. The patterned film structure was then transferred to an elastic substrate by adjusting the adhesion of a polydimethylsiloxane (PDMS) substrate to control the energy release rate. To ensure a close fit between the metal electrode and the flexible substrate, the overall structure was packaged by PDMS. Finally, a multichannel physiological signal acquisition system was built to enable electrophysiological testing and medical exploration. Compared with the traditional flexible electronic processing technology, the proposed method was more efficient and cheaper. In addition, the flexible electronic sensor was in conformal contact with skin and generated a stable signal. This investigation outlines the preliminary foundation and initial design for flexible electronics and their industrial applications.