Spectroscopy and Spectral Analysis, Volume. 32, Issue 9, 2519(2012)
New Photosensitiser 5-ALA-GNPs for Photodynamic Therapy and Its Spectral Analysis
A novel strategy by means of poly diallyl dimethylammonium chloride (PDDA) was used to make highly mono-dispersed positively charged gold nanoparticles, and 5-ALA was immobilized onto the gold nanoparticles through electrostatic interaction. The conjugation of 5-aminolevulinic acid (5-ALA) and gold nanopartilces were characterized by the integrated tools of resonance Rayleigh scattering (RRS), UV-Vis absorption spectra, transmission electron microscopy (TEM) and laser light scattering. The results demonstrated that 5-ALA can be attached onto positively charged gold nanoparticles. This new photosensitizer is significant for enhancing PDT efficacy clinically.
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YAO Cui-ping, WANG Si-jia, YANG Yang, HAN Yu-long, XU Hao, ZENG Wei-hui, ZHANG Zhen-xi. New Photosensitiser 5-ALA-GNPs for Photodynamic Therapy and Its Spectral Analysis[J]. Spectroscopy and Spectral Analysis, 2012, 32(9): 2519
Received: Apr. 7, 2012
Accepted: --
Published Online: Sep. 26, 2012
The Author Email: Cui-ping YAO (zsycp@mail.xjtu.edu.cn)