The present paper innovatively proposed the technology using hyperspectral to detect the body surface tissues that can achieve the systemic analysis of composition and structure by obtaining the multiple spectrum and image information simultaneously. Besides, by the method of data mining, the relationships between diseases and the data including the spectrum, image or synentropy were established. This technology provided more information for the disease detection clinically which can reflect accurately the physiological, biochemical and pathological status and the variation of the body surface tissues, by which both the cost of the equipment and the operation steps can be reduced.