Journal of Innovative Optical Health Sciences, Volume. 17, Issue 5, 2342001(2024)
Effect of sodium nitroprusside on the microrheological properties of red blood cells in different media
Red blood cell (RBC) aggregation as well as their deformation significantly affects blood microrheology. These processes depend on various factors, one of which is concentration of the nitric oxide, one of the main signaling molecule in the bloodstream. The purpose of this study was to investigate the effect of nitric oxide on the microrheological properties of red blood cells (RBCs) in RBC samples of various media after the addition of nitric oxide donor sodium nitroprusside in vitro. Microrheological properties were measured using laser aggregometer and ektacytometer based on diffuse light scattering and diffraction of laser light on a suspension of RBCs, respectively. The study found that heparin-stabilized blood showed increased RBC aggregation and deformation with sodium nitroprusside concentrations of 100, and 200
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Petr Ermolinskiy, Matvey Maksimov, Andrei Lugovtsov, Alexey Muravyov, Irina Tikhomirova, Alexander Priezzhev. Effect of sodium nitroprusside on the microrheological properties of red blood cells in different media[J]. Journal of Innovative Optical Health Sciences, 2024, 17(5): 2342001
Category: Research Articles
Received: Jul. 28, 2023
Accepted: Oct. 22, 2023
Published Online: Aug. 8, 2024
The Author Email: Ermolinskiy Petr (ermolinskiy.pb15@physics.msu.ru), Maksimov Matvey (madoway@yandex.ru), Lugovtsov Andrei (anlug1@gmail.com), Muravyov Alexey (alexei.47@mail.ru), Tikhomirova Irina (tikhom-irina@yandex.ru), Priezzhev Alexander (avp2@mail.ru)