In order to improve the infrared temperature measurement accuracy at the heating point under laser irradiation, a multivariate temperature compensation model was established, and the relationships among measurement distance, measurement angle and measurement accuracy were analyzed. A binary variable compensation model for measuring distance and angle was established by using single variable method and orthogonal variable method, and the error compensation model was verified by experiments. The results show that the compensation model can match the actual measurement results well. The measured error after compensation is ±125%, which improves the measurement accuracy by 64.25% compared with that before compensation. This verifies the correctness of the compensation model,which can provide theoretical guidance for infrared measurement of heating point temperature under laser irradiation.