In this paper, the atomic squeezing effects in the two-photon process with two-level atomic mixed-state are studied by means of the time-evolution operator method and numerical calculation. The results show that the squeezing properity of the atom do depend greatly on the atomic initial mixed-state, and the atomic squeezing effect is displayed periodically as 0.85 < S<1;with the increasing of the mixing extent of the atomic initial state, the characteristics of atom is getting far from squeezing state.