Journal of Innovative Optical Health Sciences, Volume. 8, Issue 1, 1530001(2015)

Elsinochrome A photosensitizers: Alternative drugs for photodynamic therapy

Tinghui Li1...2,*, Hong Deng3, Jingquan Zhao3 and Ying Gu1 |Show fewer author(s)
Author Affiliations
  • 1Department of Laser Medicine, Chinese PLA General Hospital, Beijing, People's Republic of China 100853
  • 2Department of Dermatology, 309 Hospital of PLA,
  • 3Beijing National Laboratory for Molecular Sciences (BNLMS), Key Laboratory of Photochemistry, Institute of Chemistry, Chinese Academy of Sciences, Beijing, People's Republic of China 100190
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    Photodynamic therapy (PDT) has already been a multifunctional modality for various tumors and nontumorous diseases. However, the development of photosensitizers is relatively delayed, compared with the tremendous progress in laser technology. Elsinochrome A (EA), a perylenequinonoid pigment from China, has all the typical advantages of perylenequinones. Moreover, singlet oxygen quantum yield of EA is superior to other kinds of photosensitizers and EA could be artificially biosynthesized at present, which make it an alternative candidate for PDT. In this review, the photophysics, photochemistry, photobiology and chemical or biological syntheses of EA photosensitizers are briefly presented. Besides, the future prospects of EA photosensitizers are also proposed.

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    Tinghui Li, Hong Deng, Jingquan Zhao, Ying Gu. Elsinochrome A photosensitizers: Alternative drugs for photodynamic therapy[J]. Journal of Innovative Optical Health Sciences, 2015, 8(1): 1530001

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    Paper Information

    Received: Oct. 29, 2013

    Accepted: --

    Published Online: Jul. 15, 2020

    The Author Email: Tinghui Li (drlitinghui@163.com; Hong Deng|denghong010@iccas.a)

    DOI:10.1142/s1793545815300013

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