The layout optimization of aircraft equipment cabins in limited space with various requirements of layout constraints is a complete NP problem to which is difficult to find an optimal solution. This problem is abstracted as a three-dimensional layout problem. This paper presents a new method for layout designing based on multi-constraint handling to solve the layout design problem.Firstlythe layout constraint priority is determined according to the layout space and the importance of constrained objects, and then the constrained objects are laid out with certain constraint vectors in order of priority. Secondly, unconstrained objects are grouped into categories and preprocessed according to the optimization goal and searching methods.The real layout is simulated to achieve the optimum in every step, so that the unconstrained object layout problem can be solved. Finally, the method of human-computer combination is used for tuning the layout, in order to achieve the orderliness and purposefulness of the layout design.