Journal of Inorganic Materials, Volume. 37, Issue 11, 1217(2022)

Biological Property Investigation of Nitinol Surface Implanted with Tantalum

Ling WU1,2, Ji TAN1, Shi QIAN1,3, Naijian GE4, and Xuanyong LIU1,2,3、*
Author Affiliations
  • 11. State Key Laboratory of High Performance Ceramics and Superfine Microstructure, Shanghai Institute of Ceramics, Chinese Academy of Sciences, Shanghai 200050, China
  • 22. Center of Materials Science and Optoelectronics Engineering, University of Chinese Academy of Science, Beijing 100049, China
  • 33. Cixi Center of Biomaterials Surface Engineering, Ningbo 315300, China
  • 44. Eastern Hepatobilialy Surgery Hospital, Naval Medical University, Shanghai 200438, China
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    Nitinol vascular stent can trigger thrombosis and restenosis, but lacks the ability to rehabilitate with injury still to the blood vessel wall. Thus, surface modification to the stent is indispensable for nitinol surfaces to realize biological functions of anticoagulation and accelerate endothelialization. Here, tantalum ions were implanted into nitinol surfaces by plasma immersion ion implantation and deposition (PIII&D). Physicochemical and biological characteristics of the modified nitinol surfaces were analyzed. The results show that the Ta, Ta/Ta2O5, and Ta/Ta2O5-x/Ta2O5-containing modified layers are formed on nitinol surfaces with extension of implantation time. Among all samples, the modified surface containing Ta/Ta2O5-x/Ta2O5 phase possesses better hydrophilicity and provides more sites for cell attachment to promote initial cell adhesion and proliferation. Compared with the solely Ta-bearing surface, the modified surface containing Ta/Ta2O5-x/Ta2O5 shows superior hemocompatibility, on which fewer adhered platelets are observed, maitaining an inactive and original spherical shape. Besides, the hemolysis rates of all samples are far below the threshold value of 5%, indicating that hemolysis hardly happens. The results indicate that Ta ion implantation modified nitinol stent has a potential application in reducing thrombosis and accelerating endothelialization.

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    Ling WU, Ji TAN, Shi QIAN, Naijian GE, Xuanyong LIU. Biological Property Investigation of Nitinol Surface Implanted with Tantalum[J]. Journal of Inorganic Materials, 2022, 37(11): 1217

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    Paper Information

    Category: RESEARCH ARTICLE

    Received: Mar. 13, 2022

    Accepted: --

    Published Online: Jan. 12, 2023

    The Author Email: LIU Xuanyong (xyliu@mail.sic.ac.cn)

    DOI:10.15541/jim20220140

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