The synergistic stabilization effect of different metal lanolin fatty acids as natural-based thermal stabilizers for poly (vinyl chloride) (PVC) including calcium lanolin fatty acid (Calan2), zinc lanolin fatty acid (Znlan2) and Lanthanum lanolin fatty acid (Lalan3) were studied. The processability of PVC was tested by torque rheometer, the mechanical properties were studied by universal testing machine, and the coupling effect of product in PVC/CaCO3 was also researched. The results indicated that the properties of Lan/Zn stabilizer was better than Ca/Zn stabilizer and compound lead salt except static stability and dynamic stability.