The deuterium (D2) treatment of low water peak single-mode fiber (LWP-SMF) after drawing has been investigated. The D2 treatment time and concentration have important effect on fiber’s properties after D2 treatment. The insufficient treatment of D2 cannot ensure fiber resistant to hydrogen aging, whereas excessive treatment of D2 will result in excess loss on fiber at 1383 nm. The optimization on viscosity match between the core and the cladding is helpful on problem solving of excess loss after the D2 treatment. However, by designing proper time and D2 concentration in the D2 treatment process, it can produce fiber with good hydrogen aging resistance and low excess loss and lower the cost of the D2 treatment process.