Wavefront coding (WFC) is used to extend the field depth of an incoherent optical system by employing a phase mask on the pupil. We uses a Fisher information (FI) metric based optimization method to design a phase mask by taking the modulation transfer function (MTF) of the practical optical system into consideration. This method can modulate the wavefront so that the point spread function and optical transfer function are insensitive to the object distance. The simulation results show that the optimized phase mask based on the proposed method can further improve the defocusing image quality while maintaining the focusing image quality.