In this paper, degenerate four- wave mixing in borosilicate glasses doped with crystallites of the mixed semiconductor CdSxSe1-x is reported. When the experiments were performed with the light pulse at wavelength A=0.532 μm, pulse-durations tp=8 ns and tp=6 ps, these semiconductor-doped glasses exhibit third-order nonlinearities x(3) of -10-9～10-8esu and -10-11 esu for DFWM with 10 ns and 6 ps laser pulses, respectively. The experimentally measured decay time of the gratings is 30 ps, with a time resolution of 6 ps.