The content of Bromine was measured by X-ray fluorescence approach in order to study the spatial distribution characteristics of Bromine in seawater and analyze the reasons that affect the distribution of Bromine near the Eastern shore of Leizhou Peninsula. First, the calibration curve of standard solution is obtained by small-focus X-ray fluorescence spectrometer and direct injection method, and the linear fitting equation is derived from the relationship between the fluorescence intensity and the mass concentration of Bromine, to detect the mass concentration of Bromine in coastal waters. Then, we further analyze the influences of the land runoff, tide and the structure of circulation on the distribution of Bromine in seawater in the east of Leizhou Peninsula based on the spatial variation of Bromine mass concentration in water, the spatial distribution of land runoff, tide and the structure of circulation. The Bromine mass concentration of 18 stations in the east of Leizhou Peninsula is in the range of 50.79?62.11 mg/L derived by the X-ray fluorescence spectrometry approach, and the results indicate that the content of Bromine in this area is less than that in the ocean and varies greatly with space. In this area, the Bromine content almost increases with the distance between the sampling site and two-bays-one-island (Zhanjiang bay, Leizhou bay and Naozhou island) increasing. In addition, in the south of this area and the entrance of Qiongzhou Strait, for the complex influences of currents, the Bromine content increases along the flow direction of Qiongzhou Strait. The variation of Bromine mass concentration in coastal waters demonstrates that the distribution of Bromine is uneven, and the uneven distribution fact of Bromine is mainly caused by the land runoff, tide, alongshore current near Western Guangdong, Qiongzhou Strait current, and cyclonic circulation.