Remote sensing camera image transmission interface performance is an important indicator that affects the overall performance of the camera. In order to improve the circle image data transmission rate and at the same time to meet the needs of lightweight and miniaturization for multi-channel cameras, this article proposes a multi-channel high-speed image data transmission scheme with high throughput and low bit error rate for small and medium-sized cameras. The scheme is based on CoaXPress interface using the Aurora 8B/10B communication protocol, and downstream high-speed image transmission is achieved through the FPGA high-speed serial transceiver GTX for four sets of focal plane components, with the test data rate up to 13 Gbps and the upstream camera control data rate of 21 Mbps. Simulation and test results show that the scheme greatly improves the camera’s image data transmission rate and has a nearly 50% reduction in the interface cable number compared with the traditional methods, which can meet the demand for multi-channel high-speed image transmission of light and small remote sensing cameras, and provide a new solution for the high-speed miniaturization of various types of remote sensing cameras.