The purpose of using copper slag tailings as filler on the performance of asphalt mixture, the physical and chemical properties of copper slag tailings were analyzed, the optimum mix ratio of asphalt mixture was determined through Marshall stability test. Rutting test, split test, freeze-thaw split test, and immersion Marshall test were carried out to evaluate the road performance of asphalt mixture, and the copper slag tailings asphalt pavement was tested. The adhesion characteristics of copper slag tailings and asphalt were analyzed by microscopic morphology. The results show that the content of copper slag tailings in AC-25C, AC-20C, AC-16C and AC-13C asphalt mixture is 4%, 3%, 3% and 2% (mass fraction) respectively, and the asphalt mixture has the best performance when the corresponding asphalt content is 38%, 42%, 45% and 46% (mass fraction). Compared with limestone asphalt mixture, the high-temperature stability, crack resistance and water stability of copper slag tailings asphalt mixture have been significantly improved. Copper slag tailings asphalt pavement has good performance. Its water permeability coefficient is 62 mL/min, friction coefficient is 90, and compactness is 96.4%, all of which meet the specifications and standards. The asphalt mortar formed by copper slag tailings and asphalt has good bonding performance.