To solve the problem of the vignetting resolution in mosaic CCD camera imaging based on reflector, the multi-radiance vignetting correction algorithm is studied. Firstly, the main reasons of the typically Reflector-based mosaics camera’s vignetting phenomenon were analyzed. Then, analyzing the vignetting images under multi-radiance levels in radiometric calibration experiment, each pixel’s DN (Digital Number) in vignetting imaging region is increasing with the rise of the incident radiance, nearly linear relationship. Finally, the each pixel’s correction factors in vignetting imaging region were calculated using the multi-radiance vignetting correction algorithm, and the correction factors were used to correct vignetting image. In correcting experiments, the original vignetting images’ non-uniformity is above 10%, and corrected images’ non-uniformity is reduced to below 0.5%. Correcting results meet the requirments of non-uniformity of the reflector-baesd mosaics camera.