Due to its excellent chemical stability and thermal stability, neutral pharmaceutical glass is widely used in pharmaceutical, food and other packaging fields. In this paper, the effects of oxide refining agent CeO2, halide refining agent NaCl, and compound refining agent NaClCeO2 and NaClCeO2NaNO3 on the clarification effect of neutral pharmaceutical glass were studied. The changes of area fraction, number of bubbles, and mean bubble size were quantitatively analyzed, and the refining agent suitable for neutral medical glass was explored. The research results show that after adding NaClCeO2NaNO3 to the neutral pharmaceutical glass liquid, the area fraction and number of bubbles are smaller, and the mean bubble size is larger. Thus, the clarification effect of adding NaClCeO2NaNO3 is better than adding NaCl and CeO2. When 0.4% （mass fraction） NaCl0.20% （mass fraction） CeO20.005 0% （mass fraction） NaNO3 is added, within 3 h after the temperature raising to 1 550 ℃, the area fraction of neutral pharmaceutical glass is reduced to 0.6%, the number of bubbles is reduced to 3, and the mean bubble size is 0.60 mm, the clarification effect is better.