In order to improve the positioning accuracy of the laser spot center and realize the function of laser stabilization output, this paper proposes the laser stabilization integrated system based on four-quadrant detector. First, according to the working principle of the four-quadrant detector, theoretical calculates and analyzes the center position and deviation of spot on the four quadrant detector, then, combines the computer signal processing technology and control technology, closed-loop control of the four-quadrant detector signal acquisition device and integration of the four-quadrant detector and optical components in a multi-axis cage structure, completed the design of the laser stabilization integrated system. experimental data result for many times show that the system can 100% complete the positioning of the spot center and the stability can reach 94.74%, the maximum difference of the experimental error is 2.422 μm.