To study the applicability of solid waste replacement of concrete raw materials and the effect on concrete properties， through the orthogonal test of 16 groups of fly ash-silica manganese slag recycled concrete test blocks, the effects of fly ash volume substitution for cementitious material, silicon manganese slag volume substitution for sand, and recycled aggregate mass substitution for coarse aggregate on concrete slump, cube compressive strength and splitting tensile strength were studied under different substitution amounts. The results show that when the substitution amount of fly ash is 40% (volume fraction), the increasing rate of concrete slump is the largest, which is 14.5%, and the cube compressive strength and splitting tensile strength are reduced, and the reduction rate are 7.2% and 22.8%, respectively. The substitution of silicon manganese slag reduces the slump of concrete, and when the substitution amount of silicon manganese slag is 80% (volume fraction), the reduction rate of the compressive strength and splitting tensile strength is the smallest, which are 0.5% and 11.5%, respectively. The substitution of recycled aggregate reduces the slump of concrete, and when the substitution amount of recycled aggregate is 100% (mass fraction), the reduction rate of the cube compressive strength is 1.9%, and the reduction rate of splitting tensile strength is 12.4%. The cube compressive strength of concrete is predicted by the optimized model NSGM(1,4). The average relative error of model simulation is 0.542%, and the average relative error of model prediction is 2.727%.