Spectroscopy and Spectral Analysis, Volume. 32, Issue 4, 930(2012)
Effect of Path-Length Variations on PLSR Calibration Model in Noninvasive Measurement of Blood Glucose by Mid-Infrared Spectroscopy
In noninvasive blood glucose measurement, it is difficult to keep the contact area between skin and internal reflectance element uniform while the mid-infrared spectra of human skin are taken, and this would lead to path-length variations. To study the effect of path-length variations on PLSR calibration model, in the present paper, according to the correlation coefficients between path-lengths and glucose concentrations, two PLSR models were achieved respectively and RMSECV were 31.3 and 4.52 mg·dL-1, RMSEP were 30.3 and 98.7 mg·dL-1 for the validation set. The results show that the chance correlations between path-lengths and glucose concentrations will lead to calibration models with different accuracy and robustness. This is useful to improving the reliability of noninvasive measurement of blood glucose by mid-infrared spectroscopy.
Get Citation
Copy Citation Text
WANG Dong-min, LU Qi-peng, DING Hai-quan, HUANG Fu-rong. Effect of Path-Length Variations on PLSR Calibration Model in Noninvasive Measurement of Blood Glucose by Mid-Infrared Spectroscopy[J]. Spectroscopy and Spectral Analysis, 2012, 32(4): 930
Received: Aug. 21, 2011
Accepted: --
Published Online: Apr. 16, 2012
The Author Email: Dong-min WANG (wdongmin@126.com)