Journal of Innovative Optical Health Sciences, Volume. 9, Issue 6, 1650022(2016)

A Leukocyte image fast scanning based on max–min distance clustering

Yapin Wang and Yiping Cao*
Author Affiliations
  • Department of Optical Electronics Sichuan University, Chengdu Sichuan 610064 P. R. China
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    A leukocyte image fast scanning method based on max-min distance clustering is proposed. Because of the lower proportion and uneven distribution of leukocytes in human peripheral blood, there will not be any leukocyte in lager quantity of the captured images if we directly scan the blood smear along an ordinary zigzag scanning routine with high power (100x) objective. Due to the larger field of view of low power (10x) objective, the captured low power blood smear images can be used to locate leukocytes. All of the located positions make up a specific routine, if we scan the blood smear along this routine with high power objective, there will be definitely leukocytes in almost all of the captured images. Considering the number of captured images is still large and some leukocytes may be redundantly captured twice or more, a leukocyte clustering method based on max–min distance clustering is developed to reduce the total number of captured images as well as the number of redundantly captured leukocytes. This method can improve the scanning efficiency obviously. The experimental results show that the proposed method can shorten scanning time from 8.0–14.0 min to 2.5–4.0 min while extracting 110 nonredundant individual high power leukocyte images.

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    Yapin Wang, Yiping Cao. A Leukocyte image fast scanning based on max–min distance clustering[J]. Journal of Innovative Optical Health Sciences, 2016, 9(6): 1650022

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    Paper Information

    Received: Aug. 20, 2015

    Accepted: Nov. 24, 2015

    Published Online: Dec. 27, 2018

    The Author Email: Cao Yiping (ypcao@scu.edu.cn)

    DOI:10.1142/s179354581650022x

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