It is difficult to accurately realize the multi-component quantitative analysis simultaneously, when applying open path Fourier transform infrared spectroscopy (OP-FTIR) into the remote sensing of cloud cluster because of the existence of some unknown interference materials. Combined the standard spectrum addition with matrix projection operation and target transformation factor analysis, the unknown interference components can be identified and multi-component quantitative analysis was realized simultaneously. The mixed spectrum of SF6 , methanol and NH3 were simulated to predict the concentration of SF6 and methanol while NH3 was regarded as the interference component. The results and the real concentration path-length matched fairly well.