Chinese Physics B, Volume. 29, Issue 10, (2020)

Computational prediction of RNA tertiary structures using machine learning methods

Bin Huang1,2, Yuanyang Du1,2, Shuai Zhang1,2, Wenfei Li1,2, Jun Wang1,2, and Jian Zhang1,2、†
Author Affiliations
  • 1National Laboratory of Solid State Microstructures, School of Physics, Collaborative Innovation Center of Advanced Microstructures, Nanjing University, Nanjing 20093, China
  • 2Institute for Brain Sciences, Kuang Yaming Honors School, Nanjing University, Nanjing 10093, China
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    RNAs play crucial and versatile roles in biological processes. Computational prediction approaches can help to understand RNA structures and their stabilizing factors, thus providing information on their functions, and facilitating the design of new RNAs. Machine learning (ML) techniques have made tremendous progress in many fields in the past few years. Although their usage in protein-related fields has a long history, the use of ML methods in predicting RNA tertiary structures is new and rare. Here, we review the recent advances of using ML methods on RNA structure predictions and discuss the advantages and limitation, the difficulties and potentials of these approaches when applied in the field.

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    Bin Huang, Yuanyang Du, Shuai Zhang, Wenfei Li, Jun Wang, Jian Zhang. Computational prediction of RNA tertiary structures using machine learning methods[J]. Chinese Physics B, 2020, 29(10):

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    Paper Information

    Received: Jun. 27, 2020

    Accepted: --

    Published Online: Apr. 21, 2021

    The Author Email: Zhang Jian (jzhang@nju.edu.cn)

    DOI:10.1088/1674-1056/abb303

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