To solve the problem of fighter's autonomous attack with air-to-air missile in air combat an Iterative Optimization Aiming Guidance (IOAG) method was proposed.Firstly the problems in autonomous interception attack were analyzed.Then the basic idea about IOAG was introduced and the equations of aiming error were deduced.And subsequently the model of IOAG was established and the process of IOAG was designed.Finally simulation was made for comparing it with the method of proportional navigation control and the robustness experiment was performed.The results show that the method of IOAG is very effective for the problems of autonomous interception attack.