Spectroscopy and Spectral Analysis, Volume. 34, Issue 3, 652(2014)
Noninvasive Detection of Hematocrit and the Mean Corpuscular Hemoglobin Concentration Levels by Vis-NIR Spectroscopy
Hematocrit(HCT) and mean hemoglobin concentration(MCHC) play a very important role in preventing cardiovascular disease and anemia A method was developed on the basis of spectroscopy to detect HCT and MCHC non-invasively and accurately The anatomical study showed that the blood rheology abnormalities and blood viscosity’s changes can cause the changes of tongue, so there is a certain correlation between tongue and blood components Reflectance spectrums from the tongue tips of 240 volunteers were collected, then the tongue pictures were captured and the biochemical analysis results were recorded at the same time The 240 samples were separated into two parts: calibration sample and test sample Spectra were then subjected to a partial least squares regression (PLSR) analysis to develop mathematics models for predicting HCT levels The correlation between the data and prediction of HCT and MCHC yielded calibration samples value of 0998 and 0938 HCT and MCHC levels of test samples predicted by this model from Visible-Near infrared spectra provided a coefficient of determination in prediction of 0979 and 0883 with an average relative error of prediction of 165% and 188%, a root mean square error of prediction of 4066 and 4139 From the experiment results we can see that the model which was built before can better predict the HCT and MCHC, and the results also showed that spectrometry method may provide a promising approach to the noninvasive measurement of human HCT and MCHC with a combination of PLSR analysis
Get Citation
Copy Citation Text
ZHAO Jing, LIN Ling, LU Xiao-zuo, LI Gang. Noninvasive Detection of Hematocrit and the Mean Corpuscular Hemoglobin Concentration Levels by Vis-NIR Spectroscopy[J]. Spectroscopy and Spectral Analysis, 2014, 34(3): 652
Received: Jun. 3, 2013
Accepted: --
Published Online: Mar. 14, 2014
The Author Email: Jing ZHAO (ydangliu@163.com)