To correct the nonuniformity of long-wave infrareddetectors, a nonuniformity correction method based on statistical consistency of adjacent pixels is proposed. First, the model of radiance nonuniformity is introduced. Then, the ratio between adjacent pixels is estimated with a mean operator, and the correction coefficients are calculated iteratively. Finally, a principle prototype is set up to grab different scenes. Experimental results demonstrate that the proposed method can decrease the roughness of the corrected images from 1.27×10－2 to 1.13×10－2, and the local standard deviation from 10.5 to 3.5, compared with the calibration-based method. The proposed method can reduce nonuniformity noise of infrared detectors effectively.