A control system for 1470-nm high-power semiconductor laser lipolysis was designed to realize safe and stable operation. The driving module, temperature control module, main control module, and man-machine interaction module of the control system were studied. First, a field-programmable gate array and a power feedback loop were used to realize a digitally controlled constant current source and constant power control, respectively, to drive the 1470-nm high-power laser and weak laser red indicator. SCM was responsible for the implementation of RS232 protocol analysis. Second, the digital analog proportional-integral-derivative control was used to drive a thermoelectric cooler according to the feedback of the negative temperature coefficient to realize the temperature control of the laser. Then, the microprocessor-based master control module and human-computer interaction module were designed to realize the display and storage of the output data and the driving of the touch screen. Finally, the Microcontroller Development Kit platform was used to carry out intermodulation and testing of the whole machine control system. The experimental results show that the deviation between the output power and the set power is less than 2%, and the safety performance of the entire device conforms to the national standard of medical electrical safety. The proposed control system can satisfy the requirements of 1470-nm high-power semiconductor laser lipolysis and ensure high safety and strong antijamming and stabilization.