Journal of Innovative Optical Health Sciences, Volume. 17, Issue 3, 2450003(2024)

Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image

Yiwei Chen1...2, Yi He1,2,*, Hong Ye1, Lina Xing1,2, Xin Zhang1,2, and Guohua Shi1,23 |Show fewer author(s)
Author Affiliations
  • 1Jiangsu Key Laboratory of Medical Optics, Suzhou Institute of Biomedical Engineering and Technology, Chinese Academy of Sciences, Suzhou 215163, P. R. China
  • 2School of Biomedical Engineering (Suzhou), Division of Life Sciences and Medicine, University of Science and Technology of China Hefei 230026, P. R. China
  • 3Center for Excellence in Brain Science and Intelligence Technology, Chinese Academy of Sciences, Shanghai 200031, P. R. China
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    The prediction of fundus fluorescein angiography (FFA) images from fundus structural images is a cutting-edge research topic in ophthalmological image processing. Prediction comprises estimating FFA from fundus camera imaging, single-phase FFA from scanning laser ophthalmoscopy (SLO), and three-phase FFA also from SLO. Although many deep learning models are available, a single model can only perform one or two of these prediction tasks. To accomplish three prediction tasks using a unified method, we propose a unified deep learning model for predicting FFA images from fundus structure images using a supervised generative adversarial network. The three prediction tasks are processed as follows: data preparation, network training under FFA supervision, and FFA image prediction from fundus structure images on a test set. By comparing the FFA images predicted by our model, pix2pix, and CycleGAN, we demonstrate the remarkable progress achieved by our proposal. The high performance of our model is validated in terms of the peak signal-to-noise ratio, structural similarity index, and mean squared error.

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    Yiwei Chen, Yi He, Hong Ye, Lina Xing, Xin Zhang, Guohua Shi. Unified deep learning model for predicting fundus fluorescein angiography image from fundus structure image[J]. Journal of Innovative Optical Health Sciences, 2024, 17(3): 2450003

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    Paper Information

    Category: Research Articles

    Received: Oct. 19, 2023

    Accepted: Feb. 19, 2024

    Published Online: Apr. 26, 2024

    The Author Email: He Yi (heyi@sibet.ac.cn)

    DOI:10.1142/S1793545824500032

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