A simulation of performance of thermal management with variable doping gain medium in active mirror configuration of laser diode pump solid-state laser is reported. The parameters of temperature, temperature gradient, stress, strain and optical distortion for a conventional amplifying medium and several variable doping media for different doping distributions, in active mirror configuration amplifier with pumping in the front surface and cooling in the back are simulated and compared. The calculation indicates a positive result that the variable doping media can ameliorate the problem of heating and cooling in different surfaces in active mirror configuration, and can elevate the thermal, optical and mechanical performances for laser diode pump solid-state laser (DPSSL) system. The simulation results prove the feasibility for ameliorating thermal management performances in DPSSL by variable doping media.