Based on Fluent which is a computational fluid dynamics (CFD) analysis software, a new hybrid multiphase flow model is proposed based on the equivalent viscosity for the solid- liquid two- phase containing nanoparticles impinging jet flow, and it is compared with the discrete phase model (DPM) considering interactions and no interaction. It demonstrates the comparative analysis of the calculations of three models under different solid concentrations, and meanwhile, illustrates the effects that three models have on, in terms of radial velocity, axial velocity and dynamic pressure of the work-plane, and outlet velocity of the nozzle as well as dynamic pressure and velocity of the axis, thus providing the scope of application of the three models. The research results show that when the volume fraction of nanoparticle is less than 10%, the model with equivalent viscosity, which replaces the DPM without the consideration of interaction, can be used for calculation. Finally appropriate computational model is proposed based on the scope of deviation rate.