Journal of Innovative Optical Health Sciences, Volume. 15, Issue 6, 2230009(2022)
Cerium-based nanoparticles for cancer photodynamic therapy
Metal- and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy (PDT). Among these materials, cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties, especially the reversible transition between the valence states of Ce(III) and Ce(IV). In this review, the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed, and the activation mechanisms for electron transfer to generate singlet oxygen are presented. In addition, the types of cerium-based nanoparticles used for PDT of cancer are summarized. Finally, the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed.Metal- and metal-oxide-based nanoparticles have been widely exploited in cancer photodynamic therapy (PDT). Among these materials, cerium-based nanoparticles have drawn extensive attention due to their superior biosafety and distinctive physicochemical properties, especially the reversible transition between the valence states of Ce(III) and Ce(IV). In this review, the recent advances in the use of cerium-based nanoparticles as novel photosensitizers for cancer PDT are discussed, and the activation mechanisms for electron transfer to generate singlet oxygen are presented. In addition, the types of cerium-based nanoparticles used for PDT of cancer are summarized. Finally, the challenges and prospects of clinical translations of cerium-based nanoparticles are briefly addressed.
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Hui Li, Min Wei, Xinyi Lv, Yanling Hu, Jinjun Shao, Xuejiao Song, Dongliang Yang, Wenjun Wang, Buhong Li, Xiaochen Dong. Cerium-based nanoparticles for cancer photodynamic therapy[J]. Journal of Innovative Optical Health Sciences, 2022, 15(6): 2230009
Category: Research Articles
Received: May. 9, 2022
Accepted: Aug. 24, 2022
Published Online: Nov. 25, 2022
The Author Email: Yang Dongliang (yangdl1023@njtech.edu.cn), Dong Xiaochen (iamxcdong@njtech.edu.cn)