High power microwave is easy to enter the system through the main coupling path of interconnection cables between electronic devices, disrupting or even damaging sensitive circuits or devices. To guide the rational wiring in engineering and improve the survival ability of electronic system under high power microwave, the coupling effect between HPM and cable under different parameters (cable length, height from ground, terminal load resistance, radiation field incidence angle) is systematically studied by combining simulation analysis and test verification. The coupling response law is obtained and the internal reasons are analyzed. The results show that with the increase of cable length, the coupling signal oscillates first and then tends to be stable gradually, and the oscillation period is equal to the wavelength of the incident wave. The coupling signal oscillates with the change of the height from the cable to the ground, and the maximum and minimum values appear when the height from the ground is odd times of 1/4 wavelength and integer times of 1/2 wavelength of the incident wave respectively. The coupling signal decreases first and then increases with the increase of terminal load resistance. When the load resistance matches the cable characteristic impedance, the coupling signal is the smallest. The coupling signal increases with the increase of the angle between the incoming wave direction and the cable layout direction, and the coupling signal is the largest when the two are perpendicular. On this basis, some optimization suggestions of cable laying in practical engineering are given, which provides guidance for system-level electromagnetic compatibility and high-power microwave protection design.