Holey fiber (HF) can have high nonlinearity and very flexible dispersion. The zero-dispersion wavelength (λ 0) of HF with high nonlinearity can be adjusted by changing the structure parameters of PCF. This can used to generate high efficient optical parametric amplification (OPA) at desired wavelength in HF. Hermite-Gaussian functions have been used to calculate the zero-dispersion wavelength of hexagon HF, calculations show that when pitch is between 1.1 μm and 2.6 μm, the λ0 of HF is around 1.55 μm, and the relation of pitch vs air hole diameter at λ0 has been given. Simulations of the OPA in HF show that gain of OPA can reach 60 dB in only 20 m HF with pump power of 10 W, or the bandwidth of OPA can reach 300 nm.