On the basis of Differential Evolution(DE) algorithm with strong capabilities of global searching, fast convergence speed, good robustness and easy to optimize complex problem,a technology of double wavelength stabilization is put forward to resolve the problems that optical fiber F-P sensor deviates from working point easily and causes the attenuation of output signal and the decrease of Ratio of Signal to Noise(RSN). The mathematic optimal model of double wavelength stabilization system is established, and structure of the system is optimized by using DE algorithm. The results indicate that the global optimal solution can be obtained in a shorter running time, the object is decreased by 89.46% and calculation error is less than 10-3. The results reported above prove that this algorithm is proper and feasible, and can be used for the structural optimization design of optical fiber F-P sensor.