Aiming at the problems of model parameter uncertainty and interference of Hypersonic Vehicles (HSVs) in cruise phase, a robust predictive sliding mode attitude control method is proposed.The sliding mode surface is designed by using the error between the actual output value and the reference trajectory, and the prediction function is introduced to predict the error, thus the sliding mode surface of the future time can be obtained.The speed-loop controller is designed by using the improved sliding mode approaching law.This method ensures the stability of the attitude system and the accurate tracking of the command signal under the condition of uncertain parameters and interference, which has strong robustness and improved control performance.The effectiveness of the method has been verified by simulation.