With the development and application of artificial intelligence and unmanned technology, the process of large-scale confrontation in future air-control operations is accelerating.The development of future air-control combat platforms and air-control combat weapons is analyzed, the main characteristics of large-scale air combat are sorted out, including high-density coordinated confrontation on combat platforms, saturated coordinated attack of air-control weapons, and network information as the basic support, and the requirements and impact of large-scale air combat on the future development of air-to-air missiles are analyzed from the aspects of combat usage, production and manufacturing, and design and development, which can provide certain technical reference for the development of air-to-air missiles in the future.