According to the principle of rotating prism multiplex holography and great depth holography, a multiplex holography with great depth by using He-Ne laser is demostrated. The technique uses reference beam path compensation and rotating prism modulation of two plane reference beams to record multiplex hologram of great depth of object field. The multiplexing number could be chosen arbitrarily. The theoretical analysis and experimental results are presented and shown well in agreement. A multiplexing technique is proposed for holographic interferometry of great depth which uses multiple reference beams to enode and record holograms. This technique can be used for observing time sequencing dynamical process of great depth of object field.