Objective:To study the effect of YAG laser ablation on macular microcirculation. in physiologic vitreous opacity.Methods:The selected 32 patients of physiological vitreous floaters, all of them were treated by YAG laser ablation in our hospital,. Were checked for best corrected visual acuity (BCVA), non - contact intraocular pressure, ocular b-ultrasound, indirect ophthalmoscopy, to measure the foveal avascular zone and macular vascular density using optical coherence tomography angiography (OCTA) before and 30 minutes after surgery, 1 week after surgery, 3 months after surgery, and 6 months after surgery. Observe and compare the changes of the above checks.Results:BCVA and non-contact intraocular pressure had no significant difference between before and after treatment (P>0.05). The vitreous floaters obviously decreases, after treatment. No obvious morphological changes of macular arch ring were found, no microvascular abnormalities were found. There were no significant differences in blood vessel length density and perfusion density in the central, inner and complete areas of superficial macular area.Conclusion:YAG laser ablation can safely and effectively improve the symptoms of vitreous opacity, and has no adverse effects on the visual acuity, intraocular pressure and macular microcirculation