In order to meet the radiometric calibration requirements of space payloads for large aperture and high radiance ultraviolet (UV) integrating spheres, a large integrating sphere radiation source with an inner diameter of 2200 mm, an exit aperture diameter of 800mm and a fully pressed PTFE coating is developed by a new technology. The thickness of the PTFE coating is 25 mm. The integrating sphere has a 10 kW halogen lamp light source and two external 14 kW xenon lamp light sources with an electric aperture,which can achieve a 4 orders of magnitude of large dynamic range adjustment. The radiance of the integrating sphere at 250 nm is 0.54 μW·cm ^-2·nm ^-1·sr ^-1 and in the 279--400 nm ultraviolet band, the radiance is greater than one solar constant. The expanded uncertainty of radiance calibration is 5.28%. The performance of the UV integrating sphere is also tested, and the results show that the non-uniformity of the ultraviolet radiation source is 0.65% at 380 nm. The angular non-uniformity is better than 0.7% in the horizontal and vertical directions, and 1.05% in the ±45° directions when -20°≤θ≤20°. The influences of spectral reflectance on the surface uniformity and angular uniformity are studied. The results show that with the increase of spectral reflectance, the surface non-uniformity decreases by 0.17 percentage points and the angular non-uniformity decreases by 0.15 percentage points. In addition, the stability of the radiation source, the fluorescence effect, and the thermal balance of the system are also measured. The developed UV integrating sphere radiation source has the advantages of high brightness, large aperture, good uniformity, and high reliability in the UV band (250--400 nm). It is an ideal large-area Lamber surface source and can meet the radiation calibration requirements of aerospace payloads in UV band.