An algorithm is presented for multi-sensor image fusion using discrete wavelet frame transform (DWFT). The source images to be fused are firstly decomposed by DWFT. The fusion process is the combining of the source coefficients. Before the image fusion process, image segmentation is performed on each source image in order to obtain the region representation of each source image. For each source image, the salience of each region in its region representation is calculated. By overlapping all these region representations of all the source images, we produce a shared region representation to label all the input images. The fusion process is guided by these region representations. Region match measure of the source images is calculated for each region in the shared region representation. When fusing the similar regions, weighted averaging mode is performed; otherwise selection mode is performed. Experimental results using real data show that the proposed algorithm outperforms the traditional pyramid transform based or discrete wavelet transform (DWT) based algorithms in multi-sensor image fusion.