In order to meet the observation and operation requirements of artificial cloud and fog environment, based on the advanced active microwave laser detection and sensor loads, route meteorological instruments and cloud catalytic seeding devices equipped on a unmanned aerial vehicle (UAV) platform, three-dimensional monitoring of cloud, rain, aerosol and wind below the route, the continuous observation of conventional meteorological elements such as temperature, humidity, pressure and wind speed on the route, and the sowing of cold cloud/warm cloud catalyst are realized respectively. Furthermore, an integrated control software is designed to realize the intelligent command and control of UAV and the observation and operation loads through data information link. And an intelligent unmanned observation and operation system, which integrates the observation, operation and evaluation of artificial cloud and fog, is developed finally to achieve the goals of multi-element fine observation, cold and warm cloud efficient catalytic operation, intelligent command and control, and quantitative evaluation.