In the traditional calibration method,the MEMS-IMU for high-speed rotating projectiles cannot fully activate the error, and the calibration process is complex and the calibration efficiency is low.To solve the problems, this paper designs an automatic calibration system and method of the MEMS-IMU for high-speed rotating projectiles.Firstly, the output characteristics of the MEMS-IMU for high-speed rotating projectiles are analyzed, an error model is constructed, a twelve-position, eighteen-speed calibration scheme is designed, and the turntable rotation scheme is optimized.Through the automatic calibration system, the automatic calibration of the MEMS-IMU for high-speed rotating projectiles is realized.The experimental results show that the proposed method can achieve the automatic calibration of the MEMS-IMU for high-speed rotating projectiles.Compared with that of the traditional method, the accuracy of MEMS gyroscope on roll, pitch and yaw axes is improved by more than 98%, 72% and 73% respectively, and the accuracy of MEMS accelerometer on the three axes is improved by 53%, 47% and 7% respectively.The duration of the whole calibration process is greatly reduced, which improves the calibration efficiency.