A thermal-mechanical coupling simulation model of laser cladding high-entropy alloy is established herein to break through the technical bottleneck that the laser cladding high-entropy alloys on the surface of the inner cylinder of the pump easily form cracks. The model considers the changes of the material's thermal physical properties with temperature， latent heat， laser power， and laser scanning speed as the main independent variables. The simulation results show that the high temperature gradient is mainly concentrated in the laser cladding region and its vicinity because the laser cladding process has a local rapid heating and cooling characteristics. Due to the non-unifomity of the spatial distribution of the temperature of the laser cladding high-entropy alloy and the asymmetry of the geometric structure of the laser irradiated area， the maximum tensile residual stress in x direction is greater than that in y and z directions. The stress concentration exists in the interface region between the cladding region and the matrix because of the influence of the geometric structure mutation and the temperature gradient in the region. Due to the formation of residual stress is related to temperature gradient， temperature level， structure constraints， and other factors related， therefore， with the increase of laser power， the maximum residual stress in x direction increases， the maximum residual stress in y direction decreases and then increases，and the residual stress in z direction increases. The maximum residual stress in x direction decreases with the increase of the scanning speed， the maximum residual stresses in y and z directions increase and then decrease. With the increase of laser scanning speed， the maximum tensile residual stress increases under the comprehensive competition of the reduction of thermal expansion deformation caused by the decrease of temperature and the influence of uncoordinated deformation on stress. The simulation model is verified by experiments， and the verification result proved the correctness of the model.