A special type of waveguides consisting of photonic crystal waveguide and random media is investigated. Based on the photonic crystal waveguide model, a new kind of photonic crystal waveguides with random media is put forward. In this paper, by employing the finite-difference time-domain (FDTD) method, the influences of the embedded ZnO random particles on the frequency, time-domain, gain characteristics of photonic crystal waveguide are studied. The simulation results demonstrate that in the present of random media in the defect layer of photonic crystal, the light in the defect area is obviously amplified, and the localization level is higher than the pure random media and photonic crystal waveguide, respectively. In addition, the interaction time between the random gain medium and the light is lengthened and the threshold is reduced. The waveguide can be used in the field of integrated optical system and microlaser with low threshold.