A novel space optical switch device of optofluidic is proposed to solve the problems of electrical controlling without mechanical device.The basic structure of the switch includes a core exchange space sandwiched between two optical arrays.The basic unit of array is made from liquid prism as a beam control unit including three kinds of immiscible liquids(water / oil / water).Through the electro-wetting effect,the beam deflection angle of the liquid prism can be adjusted about －15 °~15 °continuously in a specific voltage range(30 ~ 110 V).Thus one can construct a variety of two-dimensional or even three-dimensional optical switch array.