A brief review on biconical tapered fiber sensors for biosensing applications is presented. A variety of configurations and formats of this sensor have been devised for label free biosensing based on measuring small refractive index changes. The biconical nonadiabatic tapered optical fiber offers a number of favorable properties for optical sensing, which have been exploited in several biosensing applications, including cell, protein, and DNA sensors. The types of these sensors present a low-cost fiber biosensor featuring a miniature sensing probe, label-free direct detection, and high sensitivity.